According to the DHHS 2011 updated of the PHS federal regulations, the threshold amount for reporting a significant financial interest (investigator and his/her spouse and dependents) is:

• Greater than $5,000 of ownership in any single public entity/company.
• $25,000 and 5% of ownership in any single entity/company.
• Greater than $2,000 or 2% of ownership in any single entity/company.
• Greater than $10,000 or 5% of ownership in any single entity/company.

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